| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370413 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
The construction of a EP4 antagonists pharmacophore model and the discovery of a highly potent oxepinic series of EP4 antagonists is discussed. Compound 1a exhibits an excellent selectivity profile toward EP2 receptor subtype and low cytochrome P450 inhibition potential.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis, pharmacophore modeling and in vitro activity of 10,11-dihydrodibenzo[b,f]oxepine-4-carboxamide derivatives as novel and potent antagonists of the prostaglandin EP4 receptor](/preview/png/1370413.png "First Page Preview: Synthesis, pharmacophore modeling and in vitro activity of 10,11-dihydrodibenzo[b,f]oxepine-4-carboxamide derivatives as novel and potent antagonists of the prostaglandin EP4 receptor")
Authors
Luigi Piero Stasi, Kanji Bhimani, Manuela Borriello, Luca Canciani, Gianfranco Caselli, Fabrizio Colace, Cristian Ferioli, Mehul Kaswala, Laura Mennuni, Tiziana Piepoli, Sabrina Pucci, Matteo Salvi, Vikas Shirsath, Tiziano Zanelli, Silvia Zerbi,