| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370415 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A series of C-21 mercapto derivatives of hydrocortisone have been synthesized and evaluated in cell based transrepression and transactivation assays. The benzothiazole derivative, compound 6 not only showed a dissociated profile in vitro functional assays but also a pharmacological profile in a Brown-Norway rat therapeutic index model of asthma that dissociated side effects (thymolysis) while maintaining efficacy against pulmonary inflammation and lung function.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Purakkattle Biju, Kevin McCormick, Robert Aslanian, Michael Berlin, Daniel Solomon, Richard Chapman, Robbie McLeod, Daniel Prelusky, Stephen Eckel, George Kelly, Michelle Natiello, Aileen House, Xiomara Fernandez, Rema Bitar, Jonathan Phillips,