| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370416 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
We describe the design, synthesis and profiling of a novel series of PDE5 inhibitors. We take advantage of an alternate projection into the solvent region to identify compounds with excellent potency, selectivity and pharmacokinetic profiles.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Robert O. Hughes, Todd Maddux, D. Joseph Rogier, Sharon Lu, John K. Walker, E. Jon Jacobsen, Jeanne M. Rumsey, Yi Zheng, Alan MacInnes, Brian R. Bond, Seungil Han,