| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370435 | Bioorganic & Medicinal Chemistry Letters | 2011 | 7 Pages |
Abstract
A multi component based synthesis involving palladium catalyzed C–C bond forming reaction has been developed as a new strategy to access systematically modified functionalized 2-aminochromenes. This MCR involves the use of bromobenzaldehyde as a key component and is highlighted by generating a new compound library. Many of these compounds showed Mycobacterium tuberculosis H37Rv chorismate mutase inhibiting properties in vitro representing the lead example of chorismate mutase inhibition by heteroarene based compounds.
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Related Topics
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Chemistry
Organic Chemistry
Authors
T. Ram Reddy, L. Srinivasula Reddy, G. Rajeshwar Reddy, Venkata Subbaiah Nuthalapati, Y. Lingappa, Sandhya Sandra, Ravikumar Kapavarapu, Parimal Misra, Manojit Pal,