| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370438 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Herein we report the discovery and SAR of a novel series of M1 agonists based on the MLPCN probe, ML071. From this, VU0364572 emerged as a potent, orally bioavailable and CNS penetrant M1 agonist with high selectivity, clean ancillary pharmacology and enantiospecific activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Evan P. Lebois, Gregory J. Digby, Douglas J. Sheffler, Bruce J. Melancon, James C. Tarr, Hyekyung P. Cho, Nicole R. Miller, Ryan Morrison, Thomas M. Bridges, Zixiu Xiang, J. Scott Daniels, Michael R. Wood, P. Jeffrey Conn, Craig W. Lindsley,