Synthesis and 2D QSAR of O-sulphonated β-aminols derivatives as novel antifungal and antibacterial agents

Synthesis of a series of β-aminol derivatives using regioselective opening reaction catalyzed by SiO2 (60–120 mesh) and O-sulphonation in THF–KOH system, comprising tert-butoxycarbonyl at secondary nitrogen and evaluate for various stains of bacteria and fungi. SAR study of synthesized compound using backward regression analysis.

Graphical abstractSynthesis of a series of O-sulfonated β-aminol derivatives as novel antifungal and antibacterial agents along with their SAR studies.Figure optionsDownload full-size imageDownload as PowerPoint slide