Article ID Journal Published Year Pages File Type
1370449 Bioorganic & Medicinal Chemistry Letters 2011 5 Pages PDF
Abstract

It has been demonstrated that once-a-day dosing of systemically-distributed SCD inhibitors leads to adverse events in eye and skin. Herein, we describe our efforts to convert a novel class of systemically-distributed potent triazole-based uHTS hits into liver-targeted SCD inhibitors as a means to circumvent chronic toxicity.

Graphical abstractStudy to convert systemically-distributed SCD uHTS hits into liver-targeting inhibitors is described.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Physical Sciences and Engineering Chemistry Organic Chemistry
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