Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370450 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Indole and its derivatives undergo smooth conjugate addition onto en-1,4-dione derived from isatin and acetophenone, in the presence of a catalytic amount of molecular iodine in acetonitrile under mild conditions to afford a novel class of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-one derivatives in good yields with high degree of 1,4-selectivity. Some of these compounds are found to exhibit modest antibacterial and antifungal properties.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
B.V. Subba Reddy, N. Rajeswari, M. Sarangapani, G. Roopa Reddy, Ch. Madan, K. Pranay Kumar, M. Srinivasa Rao,