| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370451 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF3 triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25.
Graphical abstractA series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF3 triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Lee R. Roberts, Paul A. Bradley, Mark E. Bunnage, Katherine S. England, David Fairman, Yvette M. Fobian, David N.A. Fox, Geoff E. Gymer, Steven E. Heasley, Jerome Molette, Graham L. Smith, Michelle A. Schmidt, Michael A. Tones, Kevin N. Dack,