Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370518 | Bioorganic & Medicinal Chemistry Letters | 2015 | 5 Pages |
Abstract
Mitochondrial oxidative stress has been implicated in aging, neurodegenerative diseases, diabetes, stroke, ischemia/reperfusion injury, age-related macular degeneration (AMD) and cancer. Recently, we developed two new mitochondria-targeting fluorescent probes, MitoProbes I/II, which specifically localize in mitochondria and employed both in vivo and in vitro for detection of mitochondrial oxidative stress. Here, we report the design and synthesis of these agents, as well as their utility for real-time imaging of mitochondrial oxidative stress in cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nazmiye B. Yapici, Srinivas Mandalapu, K. Michael Gibson, Lanrong Bi,