| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370543 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
Two new C12 polyketides, cladospolides E and F (1 and 2), together with four known derivatives seco-patulolides A and C (3 and 4), 11-hydroxy-γ-dodecalactone (5) and iso-cladospolide B (6), were isolated from a soft coral-derived fungus Cladosporium sp. TZP-29. Their structures, including the absolute configurations, were elucidated by spectroscopic analysis, modified Mosher’s method, and the analysis of their biogenesis. All compounds were non-cytotoxic while compounds 1 and 3–5 showed potent lipid-lowering activity in HepG2 hepatocytes.
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Related Topics
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Authors
Meilin Zhu, Huquan Gao, Chongming Wu, Tianjiao Zhu, Qian Che, Qianqun Gu, Peng Guo, Dehai Li,