Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370559 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
Three new geranylated flavanones, named as paucatalinone A (1), B (2), and isopaucatalinone B (3), were isolated from the fruits of Paulownia catalpifolia Gong Tong (Scrophulariaceae). Their structures were well determined by means of IR, MS, 1D and 2D NMR, and CD techniques. Paucatalinone A (1) is the first sample as a dimeric geranylated flavanone derivative isolated from natural products. Paucatalinone A (1) displayed good antiproliferative effects on human lung cancer cells A549 and resulted in a clear increase of the percentage of cells in G1 phase and a decrease in the percentage of cells in S and G2/M phases in comparison with control cells.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tian-yang Gao, Xing Jin, Wen-zhao Tang, Xiao-jing Wang, Yun-xue Zhao,