| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370561 | Bioorganic & Medicinal Chemistry Letters | 2015 | 5 Pages |
Abstract
A series of hybrid molecules consisting of benzophenones and N-cyclopropyl-3-methylbenzamides were synthesized and biologically evaluated as novel p38 mitogen activated protein kinase (MAPK) inhibitors. In particular, we found that compound 10g displayed potent p38α MAPK inhibitory activity (IC50 = 0.027 μM), high kinase selectivity, and significant anti-inflammatory activity in THP-1 monocyte cells.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jinyuk Heo, Hanbo Shin, Jun Lee, Taelim Kim, Kyung-Soo Inn, Nam-Jung Kim,