| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370579 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A two-step synthetic procedure gives highly fluorescent phenanthroline molecular probes. The compounds localize in the endoplasmic reticulum and their potential as bioactive probes was evaluated. The materials are quickly taken up by living cells within 5 min. Preliminary in vitro studies have shown that these compounds are selective to esophageal cancer cells and can be used as selective markers in intracellular cancer diagnostics. The materials show a remarkable cytotoxicity towards cancer cells vs normal as 7–1.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Natalia N. Sergeeva, Marion Donnier-Marechal, Gisela M. Vaz, Anthony M. Davies, Mathias O. Senge,