| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370581 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
In this study, assisted by affinity-guided DMAP strategy, we developed a novel 19F-modified lectin as a biosensor for specific detection and imaging of glycoproteins. Exploited the large chemical shift anisotropy property of 19F nuclei, glycoproteins detected by our 19F-biosensor are signatured by broadened peaks in 19F NMR, hence enabled the distinction between glycoproteins and small molecule saccharides. Such signal on/off switching was also applied to glycoprotein imaging by 19F MRI.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yedi Sun, Yousuke Takaoka, Shinya Tsukiji, Michiko Narazaki, Tetsuya Matsuda, Itaru Hamachi,