| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370589 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A potent series of inhibitors against the B-RafV600E kinase have been developed that show excellent activity in cellular assays and good oral bioavailability in rats. The key structural features of the series are an arylsulfonamide headgroup, a thiazole core, and a fluorine ortho to the sulfonamide nitrogen.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John C. Stellwagen, George M. Adjabeng, Marc R. Arnone, Scott H. Dickerson, Chao Han, Keith R. Hornberger, Alastair J. King, Robert A. Mook Jr., Kimberly G. Petrov, Tara R. Rheault, Cynthia M. Rominger, Olivia W. Rossanese, Kimberly N. Smitheman,