| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370598 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Hydrophobic tag-assisted liquid-phase peptide synthesis technique and disulfide bond formation have been well-combined, leading to the efficient and practical preparation of a growth hormone-inhibiting peptide somatostatin. Intramolecular disulfide bond formation has successfully been carried out even under relatively high concentrations, enabling the effective peptide modifications in preparative scale.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Hydrophobic tag-assisted liquid-phase peptide synthesis has been established. ► Disulfide bond formation has been combined with hydrophobic tag. ► A growth hormone-inhibiting peptide somatostatin has been prepared. ► Intramolecular cyclization proceeds under relatively high concentrations.
