| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370606 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
An efficient synthetic route to 1,5-disubstituted 2-aminoimidazoles from readily available amino acids and aldehydes has been developed. A library of simple analogues was synthesized and several compounds were shown to exhibit notable antibiotic activity against a variety of bacterial strains including multi-drug resistant isolates.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tyler L. Harris, Roberta J. Worthington, Christian Melander,