Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370611 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A divergent synthesis of nobiletin metabolites was developed through highly oxygenated acetophenone derivative. We used commercially available methyl 3,4,5-trimethoxybenzoate as a starting material for concise preparation of the key intermediate, 2′-hydroxy-3′,4′,5′,6′-tetramethoxyacetophenone (I). These metabolites showed strong inhibitory activity against matrix metalloproteinase-9 production in human lens epithelial cells.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tetsuta Oshitari, Yuji Okuyama, Yoshiki Miyata, Hiroshi Kosano, Hideyo Takahashi, Hideaki Natsugari,