Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370614 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Optimization of adenosine analog inhibitors of bacterial NAD+-dependent DNA ligase is discussed. Antibacterial activity against Streptococcus pneumoniae and Staphylococcus aureus was improved by modification of the 2-position substituent on the adenine ring and 3′- and 5′-substituents on the ribose. Compounds with log D values 1.5–2.5 maximized potency and maintained drug-like physical properties.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Suzanne S. Stokes, Hoan Huynh, Madhusudhan Gowravaram, Robert Albert, Marta Cavero-Tomas, Brendan Chen, Jenna Harang, James T. Loch III, Min Lu, George B. Mullen, Shannon Zhao, Ce-Feng Liu, Scott D. Mills,