| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370641 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
To try and generate broad spectrum human rhinovirus VP1 inhibitors with more attractive physicochemical, DMPK and safety profiles, we explored the current SAR of known VP1 compounds. This lead to the identification of specific structural regions where reduction in polarity can be achieved, so guiding chemistry to analogues with significantly superior profiles to previously reported inhibitors.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew Morley, Nicholas Tomkinson, Andrew Cook, Catherine MacDonald, Richard Weaver, Sarah King, Lesley Jenkinson, John Unitt, Christopher McCrae, Tim Phillips,