Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities

It has been previously shown that some flavonoids inhibit NF-κB; however, the structure–activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFα induced NF-κB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Therefore, in this study, the effects of flavonoid structure on inhibition of NF-κB were investigated. Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-κB activation.

Graphical abstractIt has been previously shown that some flavonoids inhibit NF-κB; however, the structure–activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFα induced NF-κB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Therefore, in this study, the effects of flavonoid structure on inhibition of NF-κB were investigated. Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-κB activation.Figure optionsDownload full-size imageDownload as PowerPoint slide