Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370668 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Molecular modeling and phosphorylation assay in vitro were employed to select a novel unsaturated 1,3-dihydroxyisobutenyl thymine derivative 6 as ligand for HSV-1 TK which may be of interest as lead for the development of an positron emission tomography (PET) imaging agent. Compound 6 was successfully prepared using modified approaches. A significant improvement over the syntheses involving pathways A and B (1% and 3% overall yield, respectively), was observed using synthetic route C (14% overall yield).
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Authors
Svjetlana Krištafor, Ivana Novaković, Tatjana Gazivoda Kraljević, Sandra Kraljević Pavelić, Pero Lučin, Yvonne Westermaier, Lucile Pernot, Leonardo Scapozza, Simon M. Ametamey, Silvana Raić-Malić,