Article ID Journal Published Year Pages File Type
1370669 Bioorganic & Medicinal Chemistry Letters 2011 4 Pages PDF
Abstract

A new series of fused pyran derivatives 5a–x bearing 2-morpholinoquinoline nucleus has been synthesized under microwave irradiation by a reaction of 2-morpholinoquinoline-3-carbaldehyde 2a–c, malononitrile 3 and compounds 4a–h in presence of NaOH as basic catalyst. All the compounds were screened against three Gram positive bacteria (Streptococcus pneumoniae, Clostridium tetani, Bacillus subtilis), three Gram negative bacteria (Salmonella typhi, Vibrio cholerae, Escherichia coli) and two fungi (Aspergillus fumigatus, Candida albicans) using broth microdilution MIC (Minimum Inhibitory Concentration) method. Of the compounds studied, compounds 5b, 5f, 5k, 5m, 5q, 5s and 5v have found to be most efficient members of the series.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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