| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370670 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
AMPA receptors (AMPARs) have been demonstrated to be an important therapeutic CNS target. A series of substituted benzotriazinone and benzopyrimidinone derivatives were prepared with the aim to improve in vivo activity over the previously reported bis-benzoxazinone based AMPAKINE® series from our laboratory. These compounds were shown to be potent, positive allosteric AMPAR modulators that have better in vivo activity and improved metabolic stability over the analogous benzoxazinone derivatives.
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Related Topics
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Organic Chemistry
Authors
Rudolf Mueller, Stanislaw Rachwal, Steven Lee, Sheng Zhong, Yong-Xin Li, Peter Haroldsen, Todd Herbst, Susan Tanimura, Mark Varney, Steven Johnson, Gary Rogers, Leslie J. Street,