Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370672 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of phosphoramidate and phosphorothioamidate compounds based on the lead antitubulin herbicidal agents amiprophos methyl (APM) and butamifos were synthesised and evaluated for antimalarial activity. Of these compounds, phosphorothioamidates were more active than their oxo congeners and the nature of both aryl and amido substituents influenced the desired activity. The most active compound was 46, O-ethyl-O-(2-methyl-4-nitrophenyl)-N-cyclopentyl phosphorothioamidate, which was more effective than the lead compound.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christine Mara, Enda Dempsey, Angus Bell, James W. Barlow,