| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370691 | Bioorganic & Medicinal Chemistry Letters | 2015 | 5 Pages |
Abstract
Novel pyrone-derived quorum sensing (QS) ligands to inhibit the binding of OdDHL to the LasR of Pseudomonas aeruginosa were designed, synthesized and evaluated. Among the analogs, the most potent compound 8 exhibited strong in vitro inhibitory activities against biofilm formation and down-regulated OdDHL/LasR-associated genes by 35–67%. The binding mode of 8 in silico was highly similar to that of the crystal ligand OdDHL in the active site of LasR.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Suzie Park, Han-Shin Kim, Kiwon Ok, YunHye Kim, Hee-Deung Park, Youngjoo Byun,