| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370712 | Bioorganic & Medicinal Chemistry Letters | 2015 | 7 Pages |
Abstract
High-throughput screening was used to find selective inhibitors of human 15-lipoxygenase-1 (15-LOX-1). One hit, a 1-benzoyl substituted pyrazole-3-carboxanilide (1a), was used as a starting point in a program to develop potent and selective 15-LOX-1 inhibitors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Benjamin Pelcman, Andrei Sanin, Peter Nilsson, Wesley Schaal, Kristofer Olofsson, Christian Krog-Jensen, Pontus Forsell, Anders Hallberg, Mats Larhed, Thomas Boesen, Hasse Kromann, Hans-Erik Claesson,