| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370715 | Bioorganic & Medicinal Chemistry Letters | 2015 | 5 Pages |
Abstract
The design and optimization of a novel trans-1,4-dioxycyclohexane GPR119 agonist series is described. A lead compound 21 was found to be a potent and efficacious GPR119 agonist across species, and possessed overall favorable pharmaceutical properties. Compound 21 demonstrated robust acute and chronic regulatory effects on glycemic parameters in the diabetic or non-diabetic rodent models.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sangdon Han, Sanju Narayanan, Sun Hee Kim, Imelda Calderon, Xiuwen Zhu, Andrew Kawasaki, Dawei Yue, Juerg Lehmann, Amy Wong, Daniel J. Buzard, Graeme Semple, Chris Carroll, Zhi-Liang Chu, Hussein Al-Sharmma, Hsin-Hui Shu, Shiu-Feng Tung, David J. Unett,