Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370728 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The quinoxaline core is considered a privileged scaffold as it is found in a variety of biologically relevant molecules. Here we report the synthesis of a quinoxalin-6-amine library, screening against a panel of cancer cell lines and a structure–activity relationship (SAR). This resulted in the identification of a bisfuranylquinoxalineurea analog (7c) that has low micromolar potency against the panel of cancer cell lines. We also show that cells treated with quinoxalineurea 7c results in caspase 3/7 activation, PARP cleavage and Mcl-1 dependent apoptosis.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qianyi Chen, Vashti C. Bryant, Hernando Lopez, David L. Kelly, Xu Luo, Amarnath Natarajan,