| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370747 | Bioorganic & Medicinal Chemistry Letters | 2016 | 6 Pages |
Abstract
A high-throughput screening campaign has identified 1,4-diazepane compounds which are potent Cannabinoid receptor 2 agonists with excellent selectivity against the Cannabinoid receptor 1. This class of compounds suffered from low metabolic stability. Following various strategies, compounds with a good stability in liver microsomes and rat PK profile have been identified.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Doris Riether, Lifen Wu, Pier F. Cirillo, Angela Berry, Edward R. Walker, Monika Ermann, Beatriz Noya-Marino, James E. Jenkins, Dan Albaugh, Claudia Albrecht, Michael Fisher, Mark J. Gemkow, Heather Grbic, Sabine Löbbe, Clemens Möller, Kathy O’Shea,