| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370748 | Bioorganic & Medicinal Chemistry Letters | 2017 | 4 Pages |
Abstract
A novel 11C-labeled PET (positron emission tomography) tracer, which was designed based on the (phenylthio)pyrrolidine derivative that can competitively block the acromelic acid A-induced allodynia, was synthesized. A protocol in which methylation by palladium-mediated coupling of the boronate derivative with [11C]CH3I and deprotection of the protected amino acid moiety are successively performed in one-pot within 5 min was established for the synthesis of the tracer. The tracer is potentially useful as a tool to investigate the mode of action of acromelic acid A in the induction of allodynia.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masakatsu Kanazawa, Kyoji Furuta, Hisashi Doi, Tomoko Mori, Toshiaki Minami, Seiji Ito, Masaaki Suzuki,