| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370751 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
New anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2-side chain yielded analogs with improved efficacy in the rat lethal toxin model.
Graphical abstractNew anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2-side chain yielded analogs with improved efficacy in the rat lethal toxin model.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Seongjin Kim, Guan-Sheng Jiao, Mahtab Moayeri, Devorah Crown, Lynne Cregar-Hernandez, Linda McKasson, Stephen A. Margosiak, Stephen H. Leppla, Alan T. Johnson,