| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370752 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB1 receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB1 antagonist with high predicted human oral bioavailability.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Phillip M. Cowley, James Baker, Kirsteen I. Buchanan, Ian Carlyle, John K. Clark, Thomas R. Clarkson, Maureen Deehan, Darren Edwards, Yasuko Kiyoi, Iain Martin, Dawn Osbourn, Glenn Walker, Nick Ward, Grant Wishart,