8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment

Malignant gliomas continue to demand the search for improved chemotherapeutic solutions. In this work the results of a preliminary in vitro screening performed on a small library of compounds are disclosed. As a result 2-(2,4-dihydroxyphenyl)-8-hydroxy-1,4-naphthoquinone emerged as a promising therapeutic lead.

Graphical abstractA new juglone derivative showed very promising activity, in terms of apoptotic versus necrotic cell death, compared to the reference drug temozolomide in glioma cells.Figure optionsDownload full-size imageDownload as PowerPoint slide