Article ID Journal Published Year Pages File Type
1370776 Bioorganic & Medicinal Chemistry Letters 2011 6 Pages PDF
Abstract

A series of N-arylthiazole-2-amines was prepared and their biological activity for the promotion of skeletal muscle cell differentiation was investigated, a process of significant importance in muscle regeneration. A versatile new synthetic route towards the target compounds was developed and the substrate scope of this methodology was investigated. Introduction of the 2-aminoaryl substituent was carried out via nucleophilic substitution reactions in excellent yields. Furthermore, the aryl in 5-position was introduced applying a direct arylation reaction, a major improvement compared to reported synthetic routes regarding atom efficiency and sustainability.

Graphical abstractAn efficient synthetic strategy towards arylated aminothiazoles was developed based on CH-activation as key step. The obtained compounds displayed high activity to accelerate cell-differentiation of progenitor cells towards muscle cells.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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