| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370818 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Structure stability/activity relationships (SXR) of a new class of N,N-dichloroamine compounds were explored to improve antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans while maintaining aqueous solution stability. This study identified a new class of solution-stable and topical antimicrobial agents. These agents are sulfone-stabilized and possess either a quaternary ammonium or sulfonate appendages as a water solubilizing group. Several unique challenges were confronted in the synthesis of these novel compounds which are highlighted in the discussion.
Graphical abstractThis study identified a new class of solution-stable, topical, antimicrobial agents. These agents are sulfone-stabilized and possess either a quaternary ammonium or sulfonate as a water solubilizing group.Figure optionsDownload full-size imageDownload as PowerPoint slide
