| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370833 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of bromo-retrochalcones was designed, synthesized and evaluated as PTP1B inhibitors based on licochalcone A and E. Compounds 6, 12, 13, 14, 25, 36, 37, 39, and 41 showed potent inhibitory effects against PTP1B, and compound 37, the most potent among the series, had an IC50 value of 1.9 μM, about two-fold better than that of the positive control, ursolic acid.
Graphical abstractBromo-retrochalcone, 37 exhibited significant PTP1B inhibitory activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhiguo Liu, Woojung Lee, Su-Nam Kim, Goo Yoon, Seung Hoon Cheon,