| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370839 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of novel DNA-interactive C8-linked pyrrolobenzodiazepine (PBD)–heterocycle polyamide conjugates has been synthesised to explore structure/sequence-selectivity relationships. One conjugate (2d) has a greater selectivity and DNA binding affinity for inverted CCAAT sequences within the Topoisomerase IIα promoter than the known C8-bis-pyrrole PBD conjugate GWL-78 (1b).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Federico Brucoli, Rachel M. Hawkins, Colin H. James, Geoff Wells, Terence C. Jenkins, Tom Ellis, John A. Hartley, Philip W. Howard, David E. Thurston,