| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370841 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
Anaplastic lymphoma kinase (ALK) receptor tyrosine kinase is considered a promising therapeutic target for human cancers. We identified novel tetracyclic derivatives as potent ALK inhibitors. Among them, compound 27 showed strong cytotoxicity against KARPAS-299 with an IC50 value of 21 nM and significant antitumor efficacy in ALK fusion-positive blood and solid cancer xenograft models in mice without body weight loss.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kazutomo Kinoshita, Yoshiyuki Ono, Takashi Emura, Kohsuke Asoh, Noriyuki Furuichi, Toshiya Ito, Hatsuo Kawada, Shota Tanaka, Kenji Morikami, Toshiyuki Tsukaguchi, Hiroshi Sakamoto, Takuo Tsukuda, Nobuhiro Oikawa,