| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370844 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Structure–activity relationship (SAR) efforts around our initial lead compound 1 led to the identification of potent P2X7 receptor antagonists with improved pharmacokinetic profiles. These compounds were potent and selective at the P2X7 receptor in both human and rodent. Compound (entry 31) exhibited oral efficacy in the rat MIA and CCI pain models.
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Related Topics
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Organic Chemistry
Authors
Julius J. Matasi, Stephanie Brumfield, Deen Tulshian, Michael Czarnecki, William Greenlee, Charles G. Garlisi, Hongchen Qiu, Kristine Devito, Shu-Cheng Chen, Youngliang Sun, Rosalia Bertorelli, William Geiss, Van-Duc Le, Gregory S. Martin,