| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370847 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
MK2 kinase is a promising drug discovery target for the treatment of inflammatory diseases. Here, we describe the discovery of novel MK2 inhibitors using X-ray crystallography and structure-based drug design. The lead has in vivo efficacy in a short-term preclinical model.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tjeerd Barf, Allard Kaptein, Sander de Wilde, Ruud van der Heijden, Richard van Someren, Dennis Demont, Carsten Schultz-Fademrecht, Judith Versteegh, Mario van Zeeland, Nicole Seegers, Bert Kazemier, Bas van de Kar, Maaike van Hoek, Jeroen de Roos,