| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370876 | Bioorganic & Medicinal Chemistry Letters | 2015 | 5 Pages |
Abstract
This Letter describes synthesis, SAR, and biological activity of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides as inhibitors of γ-secretase mediated signaling of Notch receptors. Optimization of this series led to the identification of BMS-871 (compound 30) which displayed robust in vivo efficacy in Notch-dependent leukemia and solid tumor xenograft models.
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Related Topics
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Organic Chemistry
Authors
Weifang Shan, Aaron Balog, Claude Quesnelle, Patrice Gill, Wen-Ching Han, Derek Norris, Sunilkumar Mandal, Raja Thiruvenkadam, Kiran Babu Gona, Kamalraj Thiyagarajan, Sathiah Kandula, Kelly McGlinchey, Krista Menard, Mei-Li Wen, Anne Rose, Ronald White,