| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370881 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Dahae Lee, Ki Hyun Kim, Sung Won Moon, Heesu Lee, Ki Sung Kang, Jae Wook Lee,