| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370966 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Two scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan–Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic parameters.
Graphical abstractTwo scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan–Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic parameters.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Savithri Ramurthy, Mina Aikawa, Payman Amiri, Abran Costales, Ahmad Hashash, Johanna M. Jansen, Song Lin, Sylvia Ma, Paul A. Renhowe, Cynthia M. Shafer, Sharadha Subramanian, Leonard Sung, Joelle Verhagen,