| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370979 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
We synthesized small organic molecules designed as PDZ ligands. These indole-based compounds were evaluated for their interaction with the PDZ1 domain of the post-synaptic density 95 (PSD-95) protein. Three molecules were found to interact with the targeted PDZ protein by NMR. One of them showed chemical shift perturbations closely related to the natural ligands.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alexandre Vogrig, Benjamin Boucherle, Hemantkumar Deokar, Isabelle Thomas, Isabelle Ripoche, Lu-Yun Lian, Sylvie Ducki,