| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370981 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Quinazoline-2,4-diones with a sulfonamide group attached to the N(3) ring atom constitute a novel class of competitive AMPA receptor antagonists. One of the synthesized compounds, 28, shows nanomolar receptor affinity, whereas other examples of the series display oral anticonvulsant activity in animal models.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Manuel Koller, Kurt Lingenhoehl, Markus Schmutz, Ivan-Toma Vranesic, Joerg Kallen, Yves P. Auberson, David A. Carcache, Henri Mattes, Silvio Ofner, David Orain, Stephan Urwyler,