| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370982 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Muramyl di- and tri-peptides are putative activators of the innate immune system through stimulation of the NOD2 receptor. To provide tools for the clarification of the mechanism of this activation we isolated different UDP-muramyl tripeptides (Lys- and DAP-type) from bacteria and used them to synthesize biotinylated derivatives. All biotinylated compounds retained their ability to activate NOD2 in a cell-based test system and are therefore suitable for binding studies aimed at identifying the appropriate pattern recognition receptor(s).
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Related Topics
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Chemistry
Organic Chemistry
Authors
Nicolas Gisch, Birte Buske, Holger Heine, Buko Lindner, Ulrich Zähringer,