Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370983 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
Search for new antimicrobial agents led to the synthesis of series of N-1, C-3 and C-5 substituted bis-indoles. Their evaluation for antifungal and antibacterial activities resulted in the optimization of pyrrolidine/morpholine/N-benzyl moiety at the C-3 end and propane/butane/xylidine groups as linkers between two indoles for significant inhibition of microbial growth. Preliminary investigations have identified three highly potent antimicrobial agents. Dockings of these molecules in the active sites of lanosterol demethylase, dihydrofolate reductase and topoisomerase II indicate their strong interactions with these enzymes.
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Related Topics
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Chemistry
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Authors
Palwinder Singh, Puja Verma, Bhawna Yadav, Sneha S. Komath,