| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370992 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of metabotropic glutamate 5 receptor (mGluR5) allosteric ligands with positive, negative or no modulatory efficacy is described. The ability of this series to yield both mGluR5 PAMs and NAMs with single-digit nanomolar potency is unusual, and the underlying SAR is detailed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anette Graven Sams, Gitte Kobberøe Mikkelsen, Robbin M. Brodbeck, Xiaosui Pu, Andreas Ritzén,